USB to SERIAL converter problem

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USB to SERIAL converter problem

I have a problem with a Prolific USB to serial converter. It’s for XP, WIN 7 and WIN 8 use.
The application is running WSPR and HRD and a few other things on a PC connected to an IC-735 radio.
It works fine with a XP computer but not with a WIN 7 or WIN 8 PC. With WIN 7 and WIN 8 the radio is called but no connection is established. There is a signal train on the TXD pin but for some reason the radio is not responding or the PC SW is not detecting it. I’m not sure of which.
I’ve reinstalled the SW both with the accompanying CD and from the Internet resources to no avail.
Has anybody encountered this and perhaps found a solution?